Targeting immunosuppression by Tregs with monoclonal antibodies against GARP.
2016
ABSTRACTReducing Treg function in cancer patients should augment antitumor immune responses. We recently uncovered a mechanism of immunosuppression by human Tregs that implies transmembrane protein GARP and production of active TGF-s1. We obtained monoclonal antibodies that block this process and could thus serve as a novel approach for cancer immunotherapy.
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