CXCL13 levels are elevated in patients with Waldenstrom macroglobulinemia, and are predictive of major response to ibrutinib

Waldenstrom macroglobulinemia (WM) is characterized by bone marrow (BM) infiltration of monoclonal Immunoglobulin M (IgM) secreting lymphoplasmacytic lymphoma (LPL), and typically presents with anemia. MYD88 and CXCR4 activating somatic mutations ( CXCR4MUT ) are common in WM, and found in 90–95