uPA and uPAR expression in acute myeloid leukemia and the clinical implication

Objective To investigate the uPAR expression in bone marrow mononuclear cell(MNC) and uPA plasma level in acute myeloid leukemia(AML) and furthermore to explore the clinical importance.Methods 22 cases of diagnosed acute myeloid leukemia(AML groups) and 34 cases of benign blood diseases(control groups) were enrolled in this study.The expression of uPAR of bone marrow MNC was detected by flow cytometry and uPA plasma level was detected by ELISA in two groups.Results The uPAR expression in BM MNC and plasma level of the uPA in AML were both higher than those in control subjects.There were significant differences between groups(P0.05).Pearson correlation analysis showed a positive correlation between levels of uPA and uPAR(AML group r1=0.614,control group r2=0.921;P0.05).Conclusion The results showed that level of uPA and uPAR were over expressed in AML groups,and there was a close correlation between each other.Combined detection has clinical significance for monitoring and prognosis of acute myeloid leukemia.