Acute changes in colonic PGE2 levels as a biomarker of efficacy after treatment of the Pirc (F344/NTac-Apc am1137) rat with celecoxib

Changhong Yun,Wan-Mohaiza Dashwood,Li Li,Taijun Yin,Ahmet M. Ulusan,Katherine Shatzer,Song Gao,Ke-He Ruan,Ming Hu

Acute changes in colonic PGE2 levels as a biomarker of efficacy after treatment of the Pirc (F344/NTac-Apc am1137) rat with celecoxib

2019

Changhong Yun
Wan-Mohaiza Dashwood
Li Li
Taijun Yin
Ahmet M. Ulusan
Katherine Shatzer
Song Gao
Ke-He Ruan
Ming Hu

Objective This study sought to evaluate short-term treatment with COX-2 inhibitors and acute changes in colonic PGE2 levels as predictors of long-term efficacy in a genetic model of colorectal cancer.

Keywords:

Biomarker (medicine)
Celecoxib
Biochemistry
Prostaglandin E2
Oncology
Colorectal cancer
Diabetes mellitus
genetic model
COX-2 inhibitor
Internal medicine
Biology
Allergy
Gastroenterology

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