A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

Cory M. Johannessen,Laura A. Johnson,Federica Piccioni,Aisha Townes,Dennie T. Frederick,Melanie K. Donahue,Rajiv Narayan,Keith T. Flaherty,Jennifer A. Wargo,David E. Root,Levi A. Garraway

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

2013

Cory M. Johannessen
Laura A. Johnson
Federica Piccioni
Aisha Townes
Dennie T. Frederick
Melanie K. Donahue
Rajiv Narayan
Keith T. Flaherty
Jennifer A. Wargo
David E. Root
Levi A. Garraway

Expression of more than 15,500 genes individually in a melanoma cell line treated with RAF, MEK, ERK or combined RAF–MEK inhibitors reveals a cyclic-AMP-dependent melanocytic signalling network associated with drug resistance; this may represent a novel therapeutic target for melanoma treatment.

Keywords:

Transcription factor
Drug resistance
Melanoma
MAPK/ERK pathway
HEK 293 cells
Cancer research
Gene
Signal transduction
CREB-binding protein
Molecular biology
Biology
Mitogen-activated protein kinase
Protein kinase A
Kinase
Microphthalmia-associated transcription factor
V600E

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