Influence of two kinds of traditional Chinese medicine in expressins of B lymphocyte stimulator and IL-10 in plasma of MRL/1pr mice.

Objective To investigate the effects and the mechanisms of two lupus recipes including lupus recipe 1(LR1)and lupus recipe 2(LR2)which was traditional Chinese medicine(TCM)to the MRL/lpr mice.to provide the data and basis for the treatment of systemic lupus erythematosus with traditional Chinese medicine and combined Chinese-Western medicine.Methods 34 MRL/lpr mice were randomly divided into 6 different groups:Group A was LR1.Group B was LR2.Group C was prednisone.Group D was LR1+prednisone.Group E was LR2+ prednisone.Group F was negative control.Serum Blys and IL-10 were measured by ELISA.Results The change of Blys:The level of Blys in group A,B,C,D and E were all lower than that of group F(P0.01).Compared with group A,B or C,the group D and E were all significant lower(P0.01).The change of IL-10:Compared with the group F,the group A and B were no significant difference(P0.05).Compared with the group D and E,the group F was significant difference(P0.01),and group C was no difference(P0.05).Conclusion LR and prednisone should be effective to the treatment of MRL/lpr mice.Both of them can decrease the level of Blys.The TCM and glucocorticoid used in combination was superior to that used alone.