A genetic variant in DICER gene is associated with prognosis of hepatocellular carcinoma in a Chinese population

Aim MicroRNA (miRNA), functions as gene regulators, plays crucial roles in pathogenesis and prognosis of hepatocellular carcinoma (HCC). Genetic variants in miRNA processing genes may affect miRNAs expression and contribute to HCC risk and survival. We hypothesized that single nucleotide polymorphisms (SNPs) in miRNA processing genes may be associated with HCC susceptibility and prognosis. The study aims to verify whether this hypothesis is right or not. Methods We first genotyped the selected three SNPs in miRNA processing genes (RAN rs3803012 A > G, HIWI rs10773771 T > C, and DICER rs1057035 T > C) in 312 HCC patients and 320 cancer-free controls using the TaqMan assay, and evaluated the associations of the three SNPs with HCC risk. Then, we also investigated the effect of the three SNPs on the overall survival of 312 HCC patients. Results There was no significant associations between the three SNPs (RAN rs3803012 A > G, HIWI rs10773771 T > C, and DICER rs1057035 T > C) and HCC risk. However, HCC patients carrying DICER rs1057035 CT + CC genotypes had significantly longer median survival time (log-rank P = 0.018) and decreased death risk (adjusted HR = 0.68, 95%CI: 0.49-0.95, P = 0.022) than patients with rs1057035 TT genotypes. The DICER rs1057035 genotype was an independent protective factor for HCC survival (CT + CC vs TT: HR = 0.72, 95%CI = 0.55-0.96, P = 0.031). Conclusions This study provides evidence that DICER rs1057035 T > C polymorphism may be a prognostic biomarker for HCC patients.