Bioconcentration and Antioxidant Status Responses in Zebrafish (Danio Rerio) Under Atrazine Exposure

The present study was planned designed to investigate the chronic impacts of herbicide atrazine exposure on stress biomarkers acetylcholinesterase activity (AChE) and oxidative stress responses in brain of zebrafish (Danio rerio), and determine the bioconcentration of atrazine in whole body of fish. Chronic exposure to atrazine unveiled a markedly discourage in the activity of AChE. However, significant increase in the activities of catalase (CAT) and superoxide dismutase (SOD) and both influenced by atraizine, and CAT was over sensitivity to atrazine compared with SOD. The highest bioconcentration factor (BCF) of atrazine in the fish treated was (12.8543×10 4 and 13.5891×10 4 ) after 24h exposure to (0.957 and 1.913 mg L -1 ) and 13.238×10 4 , after 25 d exposure to 0.638 mg L −1 of atrazine respectively. This study showed that the zebrafish have ability to bioaccumulate of the herbicide atrazine rapidly. atrazine accumulation in zebrafish has a private importance due to the implication of atrazine in chronically health problems, as well as the information contained in our study is useful for understand the mechanism of atrazine induced oxidative stress in fish.