Heme oxygenase 1 is expressed in murine erythroid cells where it controls the level of regulatory heme

Heme is essential for the function of all aerobic cells. However, it can be toxic when it occurs in a non–protein-bound form; cells maintain a fine balance between heme synthesis and catabolism. The only physiological mechanism of heme degradation is by heme oxygenases (HOs). The heme-inducible