New benzimidazoles as thrombopoietin receptor agonists

Igor G. Safonov,Dirk A. Heerding,Richard M. Keenan,Alan T. Price,Connie L. Erickson-Miller,Christopher B. Hopson,Jenna L. Levin,Kenneth A. Lord,Peter Tapley

New benzimidazoles as thrombopoietin receptor agonists

2006

Igor G. Safonov
Dirk A. Heerding
Richard M. Keenan
Alan T. Price
Connie L. Erickson-Miller
Christopher B. Hopson
Jenna L. Levin
Kenneth A. Lord
Peter Tapley

Abstract A novel benzimidazole series of small-molecule thrombopoietin receptor agonists has been discovered. Herein, we discuss the preliminary exploration of structure–activity relationships within this chemotype.

Keywords:

Small molecule
Benzimidazole
Agonist
Organic chemistry
Chemical synthesis
Biochemistry
Structure–activity relationship
Bicyclic molecule
Carboxylic acid
Stereochemistry
Chemistry
Thrombopoietin
thiophene derivatives
biphenyl derivatives
benzene derivatives
Thrombopoietin Receptor Agonists

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