Copper is a potent inhibitor of the propensity for human ProIAPP1-48 to form amyloid fibrils in vitro

Christopher Exley,Matthew Mold,Emma Shardlow,Benjamin Shuker,Baritore Ikpe,Ling Wu,Paul E. Fraser

Copper is a potent inhibitor of the propensity for human ProIAPP1-48 to form amyloid fibrils in vitro

2012

Christopher Exley
Matthew Mold
Emma Shardlow
Benjamin Shuker
Baritore Ikpe
Ling Wu
Paul E. Fraser

Abstract Background: The amyloidogenic peptides IAPP and ProIAPP1-48 are implicated in β cell death in type 2 diabetes mellitus. While the mechanism of their deposition in vivo is unknown we have shown

Keywords:

In vivo
Programmed cell death
Beta sheet
Type 2 Diabetes Mellitus
Amylin
Amyloid
Biochemistry
Fibril
Chemistry
In vitro
Diabetes mellitus

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