Histopathologic Study ofEvolution ina Series of 105Surgically Treated Patients

tumorsin88% ofpatients and diffuse or multifocal tumorsin12%.Mucinousdifferentiation was present in43%ofpatients, vascular invasion in22%, andaerogenous spread in49%.Overall survival was 89%at1year, 76% at2years, 48% at5years, and39% at10years. Thesurvival curves according tohistologic features showed astatistically significant difference between diffuse lesions andnodular lesions, between lesions withandwithout aerogenous spread (diffuse lesions excluded), andbetween lesions withandwithout vascular invasion. Conclusions: Thenatural history ofBACisespecially influenced byitsnodular or diffuse nature, vascular invasion, andaerogenous spread. (CHEST 1998; 113:391-95)