PHARMACOGENETICS AND DRUG DISCOVERY FOR ANTHRACYCLINE-INDUCED CARDIOTOXICITY ENABLED BY SINOATRIAL NODE-LIKE CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS

The sinoatrial node (SAN) is the primary pacemaker of the heart. The human SAN is poorly understood due to limited primary tissue access and lack of robust in vitro derivation methods. We developed an efficient strategy, using a dual SHOX2:GFP; MYH6:mCherry knock-in reporter line, to generate and