Clinical validation of a computer-based approach for the quantification of the skin aging process of women using in-vivo confocal microscopy.

Reflectance confocal microscopy (RCM) is a powerful tool to visualize the skin layers at cellular resolution up to a depth of 200µm. A semi-quantitative score of skin aging from RCM images has been previously published, requiring visual assessment of the images by experienced dermatologists. We have proposed in a previous publication, new computer-based methods to automatically quantify the skin aging process on RCM images.