Antibacterial and Antibiofilm Activity of Barium Titanate Nanoparticles

Abstract In this research work, barium titanate nanoparticles (BaTiO 3 NPs) were prepared by a co-precipitation method using barium nitrate and titanium dioxide precursors. The structural and morphological studies of the NPs were carried out by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM). The XRD pattern confirmed the formation of the BaTiO 3 NPs having an average size less than 100 nm. BaTiO 3 NPs were also evaluated for their efficacy against the human pathogenic bacteria. Significant antimicrobial and antibiofilm activities of BaTiO 3 NPs were observed against P. aeruginosa and S. aureus clinical isolates. Results presented in this work confirm that BaTiO 3 NPs can control the growth of biofilm formation activities of pathogenic bacteria at very low concentration and hence suggests their use as alternative antimicrobial agents. This is the first report on chemical method synthesized BaTiO 3 NPs for its biofilm inhibition activity.