Efficacy of Oil Based Haemorrhagic Septicaemia Vaccine: A Field Trial

An oil adjuvanted vaccine prepared from Pasteurella multocida serotype 6:B was evaluated under field conditions for induction of immune response in cattle and buffaloes and its efficacy was compared with conventionally used Alum precipitated vaccine (APV). A total of 2703 cattle and buffaloes of various age groups (i.e., Adults, Heifers and Calves) were vaccinated with oil adjuvant vaccine (OAV). Alum precipitated vaccine was administered in 813 animals. Two hundred serum samples from vaccinated and 50 from un-vaccinated control animals were collected at regular intervals up to 360 days. Sera were tested for the presence of antibodies against P. multocida by indirect enzyme linked immunosorbant Assay (I-ELISA). Comparatively higher antibody titers were observed in animals of all age groups vaccinated with oil adjuvant vaccine throughout the trial period; while, the titres in animals vaccinated with APV declined after 3 months following vaccination and reached at minimal level 180 days post vaccination. The results justified the replacement of APV with the newly developed oil adjuvant vaccine for the control of haemorrhagic septicemia in animals.