A case of c-kit positive high-grade stromal endometrial sarcoma responding to Imatinib Mesylate

Abstract Background. High-grade endometrial stromal sarcoma (HGES) is an aggressive disease with dismal prognosis. Surgery is the standard treatment, and radiotherapy seems to reduce local relapse. No other treatment has proved to be useful in the case of non-resectable diseases. Case. A 41-year-old woman suffering HGES, with positive staining for CD117 ( c-kit ) and large abdominal and retroperitoneal mass progressing after chemotherapy, was treated with Imatinib Mesylate. After 3 months, objective response was documented and radical surgery performed. Two years after surgical intervention, she is currently free of the disease. Conclusion. The response seen with Imatinib should be further investigated in a larger number of cases.