Subacute Cutaneous Lupus Erythematosus

The concept of SCLE as a distinctive subset in the disease spectrum of lupus erythematosus has been supported by the literature over the past 20 years. It is characterised by photo-distributed non-scarring papulosquamous and/or annular skin lesions with a LE-specific histopathology. Drug-induced aetiology and overlap with Sjogren's syndrome have been documented. The pathogenetic role of UV-light and the Ro antigen-antibody system have been actively investigated. Its management includes thorough evaluation, patient education, photoprotection, topical steroids, antimalarials and a variety of other agents. It is hoped that novel forms of immunotherapy can be established in the coming decade.