Abstract 11475: A Genetically Modified pH Resistant NCX1 Mouse Prevents Calcium Overload During Acidosis and is Cardioprotective

Rui Zhang,Xiaokang Wu,Catherine B. Xie,Devina Gonzalez,Sabine Lotteau,Joice Thomas Gavali,Liang Li,Scott A. John,Kenneth D. Philipson,Michela Ottolia,Joshua I. Goldhaber

Abstract 11475: A Genetically Modified pH Resistant NCX1 Mouse Prevents Calcium Overload During Acidosis and is Cardioprotective

2021

Rui Zhang
Xiaokang Wu
Catherine B. Xie
Devina Gonzalez
Sabine Lotteau
Joice Thomas Gavali
Liang Li
Scott A. John
Kenneth D. Philipson
Michela Ottolia
Joshua I. Goldhaber

Acidosis inhibits the cardiac sodium(Na)/calcium(Ca) exchanger (NCX1), allegedly contributing to elevated cytoplasmic Na and Ca concentrations during ischemia. Upon reperfusion and restoration of n...

Keywords:

Sodium
Ischemia
Genetically modified organism
Ion transporter
Acidosis
Pharmacology
calcium overload
Cytoplasm
Medicine
Calcium

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations