Bone-Derived Factors as Potential Biomarkers for Parkinson’s Disease

Background Parkinson's disease (PD) and osteoporosis are both common aging diseases. It is reported that PD has a close relationship with osteoporosis and bone secretory proteins may be involved in disease progress. Objectives To detect the bone-derived factors in plasma and cerebrospinal fluid (CSF) of patients with PD and evaluate their correlations with C-reaction protein (CRP) level, motor impairment and Hoehn-Yahr (HY) stage of the disease. Methods We included 250 PD patients and 250 controls. Levels of osteocalcin(OCN), osteopontin(OPN), osteoprotegerin(OPG), Sclerostin (SO), Bone morphogenetic protein 2 (BMP2) and Dickkopf-1 (DKK-1) in plasma and CSF were measured by custom protein antibody arrays. Data were analyzed using Mann-Whitney U-test and Spearman’s rank correlation. Results Plasma levels of OCN and OPN were correlated with CRP levels and HY stage and motor impairment of PD. Furthermore, the plasma assessment with CSF detection may enhance their potential prediction on PD. Conclusions OCN and OPN may serve as potential biomarkers for PD. The inflammation response may be involved in the cross-talks between the two factors and PD