BIPHASIC EFFECTS OF SELECTIVE INHIBITION OF TRANSFORMING GROWTH FACTOR β1 ACTIVIN RECEPTOR-LIKE KINASE ON LPS-INDUCED LUNG INJURY

ABSTRACTThe present study was designed to find out whether SB431542, an inhibitor of transforming growth factor β1 activin receptor-like kinase, could protect the lung from LPS-induced injury. Inflammatory lung injury model was induced by intratracheal administration of LPS. C57BL/6 mice were random