One-step fabrication of chitosan sponge and its potential for rapid hemostasis in deep trauma.

Here a facile and efficient preparation strategy of porous and hydrophilic chitosan sponge is demonstrated by combining surfactant and pore-foaming agent. The obtained chitosan sponge has interconnected pore structure, soft texture, fast water absorption rate and capacity, and the compressed sponge can achieve its shape recovery in 5 s after absorbing water. Meanwhile, it could get rid of the residual acid in the chitosan sponge prepared by the acid method. Additionally, the results demonstrate the behaviour of the chitosan sponge and the ability of the better blood coagulation, compression strength and biocompatibility. It also behaves good antibacterial effect on Escherichia coli and Staphylococcus aureus. Further shows the animal experimentation of the rapid hemostasis and the chitosan sponge can be achieved within the 50 s.