Stimulation of renin secretion by the phosphodiesterase IV inhibitor rolipram.

It is now generally accepted that the renin secretory response to beta adrenoceptor stimulation is mediated by increased formation of cAMP in the juxtaglomerular cells. It is also known that renin secretion is increased when cAMP metabolism is decreased by phosphodiesterase inhibitors such as theophylline, but it is not known which isoforms of phosphodiesterase are involved. In the present study, we investigated the effect on renin secretion of the phosphodiesterase IV inhibitor rolipram in conscious rabbits. The i.v. administration of rolipram in a dose of 25 microgram/kg followed by infusion at 5 microgram/kg/min in eight rabbits increased mean arterial pressure from 82 +/- 5 to 93 +/- 6 mm Hg (P