[Efficiency of DA-EPOCH and MA chemotherapy in the mobilization of autologous peripheral blood stem cells in non-Hodgkin's lymphoma].

Objective To study the effect and safety of the DA-EPOCH chemotherapy combined with G-CSF and the MA chemotherapy combined with G-CSF on mobilizing and collecting the peripheral blood stem cells and the later hematopoietic recovery. Methods A total of 40 patients accepted mobilization and collection of peripheral blood stem cells(PBSC) after being treated by DA-EPOCH+ G-CSF and MA+ G-CSF therapy respectively, and performed auto-transfusion. The effect of mobilization, the adverse effects and the hematopoietic recovery after autologous transplantation were analyzed retrospectively. Results Two cases in DA-EPOCH group and 1 case in MA group did not achieve the collection goal and required a G-CSF mobilization therapy again. During the DA-EPOCH mobilization therapy, the lowest median WBC was[0.7(0.5, 0.9)]×109/L and the median lowest platelet (PLT) count was[75.0 (53.0, 107.0)]×109/L.Low-grade fever occurred in 7 cases (37.5-38.3 ℃) and platelet transfusion was required in 2 cases. The collection of MNC number was (5.8±1.8)×108/kg, and the median CD34+ cell number was[3.7(2.8, 6.7)]×106/kg; for the MA therapy groups, the numbers were[0.4 (0.2, 0.9)]×109/L and[12.0 (6.0, 16.0)]×109/L, respectively. High fever occurred in 8 cases (above 39 ℃). PLT transfusion was required in 15 cases and red blood cell(RBC) transfusion in 4 cases. The collected number of MNC was (6.0±2.9)×108/kg, and CD34+ median cell number was[8.5(2.6, 11.2)]×106/kg. There are significant differences between the lowest PLT counts and CD34+ cell numbers in the two groups of patients(P 0.05). No death occurred during the process of transplantation. Conclusions DA-EPOCH and MA chemotherapy could effectively mobilize the peripheral blood stem cells in suitable NHL patients.DA-EPOCH chemotherapy was higher in safety and lower in price, and required less transfusion compared with MA therapy. Key words: Lymphoma, non-Hodgkin; Hematopoietic stem cell mobilization; Chemotherapy