Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling

Genes encoding spliceosome components including SF3B1, U2AF1 , and SRSF2 , are frequently somatically mutated in myelodysplastic syndromes (MDS), other hematologic malignancies, and solid tumors.[1][1] Typically these are mutually exclusive, heterozygous, missense, hotspot mutations that result in