BPC 157 antagonized the general anesthetic potency of thiopental and reduced prolongation of anesthesia time induced by L-NAME/thiopental combination (1061.3)

We hypothesized the general anesthetic thiopental effect depending on NO-related mechanisms, consequently counteracted by stable gastric pentadecapeptide BPC 157. (i) To determine the general anesthetic effect of thiopental and possible counteraction depending on BPC 157 administration, all rats received intraperitoneally thiopental (20, 30, 40 mg/kg) while medication (BPC 157 (10 μg/kg, 10 ng/kg, 10 pg/kg) was given intraperitoneally at 5 min before thiopental. (ii) To determine NO-related mechanisms, all rats received intraperitoneally thiopental 40 mg/kg while BPC 157 (10 μg/kg), L-NAME (10 mg/kg), L-arginine (30 mg/kg) were applied alone and/or combined. BPC 157 was given at 25 min before thiopental while L-NAME, L-arginine, alone and/or combined, were applied at 20 min before thiopental. (i) BPC 157 (10 ng/kg and 10 μg/kg), caused significant antagonism of general anesthesia produced by thiopental with a parallel shift of the dose-response curve to the right. (ii) L-NAME. Thiopental-induced anesthesi...