Use Of Animal, Human And Mechanistic Evidence For The Prediction Of Hepatotoxicity

Mechanistic insight within Derek for Windows hepatotoxicity alerts was found to be used in at least two different ways. In some cases, structure-activity parallels could be drawn between hepatotoxiceffects and therapeutic action (e.g. tetracyclines). In others, an understanding of the chemical reaction implicated in hepatotoxicity could be used to derive restrictions on the scope of an alert (e.g. thiophenes).Tetracyclines