Lack of Breastfeeding History in Parous Women With Inflammatory Breast Cancer Predicts Locoregional Recurrence and Distant Metastasis

Results: Median follow-up was 7.6 years (0.1-20.0). Within the entire cohort, the majority of patients were white (90%; 6% African American (AA); 4% other), postmenopausal (89%), ER positive (88%), PR positive (74%), Her2 negative (93%), and grade 2 (48%; all p < 0.001). Endocrine therapy was given in 65% of cases (pZ0.05) and chemotherapy in 14% (p<0.001). The table demonstrates 5and 10-year LR rates, as well as univariate analysis (UVA) for factors predictive of LR. No factors were predictive for RR on UVA with the exception of grade 3 disease in all patients (pZ0.009). Nothing was predictive for CLBF except personal history of BC in cautionary patients (pZ0.03) and 1st-degree relative with BC in suitable patients (pZ0.05), both demonstrating higher rates of CLBF. The use of chemotherapy in unsuitable patients decreased the rate of CLBF (pZ0.03). Conclusion: These data suggest that other factors outside of the current ASTRO consensus guidelines should be considered in determining future guideline recommendations for early stage breast cancer patients treated with APBI. Author Disclosure: J.L. Wobb: None. M. Wallace: None. P.Y. Chen: None. C.S. Shah: None. M.S. Jawad: None. I.S. Grills: Research Grant; Elekta. J.S. Stromberg: None.