In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline.

Heidi I.L. Jacobs,John A. Becker,Kenneth K. Kwong,Nina Engels-Domínguez,Prokopis C. Prokopiou,Kathryn V. Papp,Michael J. Properzi,Olivia L. Hampton,Federico d’Oleire Uquillas,Justin S. Sanchez,Dorene M. Rentz,Georges El Fakhri,Marc D. Normandin,Julie C. Price,David A. Bennett,Reisa A. Sperling,Keith A. Johnson

In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline.

2021

Heidi I.L. Jacobs
John A. Becker
Kenneth K. Kwong
Nina Engels-Domínguez
Prokopis C. Prokopiou
Kathryn V. Papp
Michael J. Properzi
Olivia L. Hampton
Federico d’Oleire Uquillas
Justin S. Sanchez
Dorene M. Rentz
Georges El Fakhri
Marc D. Normandin
Julie C. Price
David A. Bennett
Reisa A. Sperling
Keith A. Johnson

Several autopsy studies recognize the locus coeruleus (LC) as the initial site of hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU increases, TAU pathology emerges...

Keywords:

Disease
tau pathology
cognitive decline
Autopsy
In vivo
Locus coeruleus
Neuropathology
Pathology
Medicine

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