[Clinical features of drug-induced liver injury in children].

Objective To study the clinical features of drug-induced liver injury in children.Methods The clinical data of the hospitalized children with drug-induced liver injury over 5 years were retrospectively reviewed.Results Of 641 cases of hospitalized children with liver injury,there were 64 cases(10%) of drug-induced liver injury.Hepatocellular injury was the most common type of drug-induced liver injury(81%).The major drugs causing drug-induced liver injury included chemotherapy drugs,antibiotics and anti-tuberculosis drugs.Rash(16%),gastrointestinal reaction(15%),fever(14%) and liver intumescence(12%) were common clinical symptoms.A part of patients with drug-induced liver injury(11%) had no symptoms and signs.Conclusions Drug-induced liver injury is one of the common causes of liver damage in hospitalized children.Some children with drug-induced liver injury have no symptoms and signs.Hepatocellular injury is a major type of drug-induced liver injury in children,resulting less severe liver damage.