Pharmacologic characterization in vitro and in vivo of iodine 123-labeled derivatives of the beta-adrenoceptor antagonist CGP12177, designed for the imaging of cardiac beta-receptors.

Eric A. Dubois,G. Aernout Somsen,J. D. Bos,Anton G. M. Janssen,Gerard J. Boer,Harry D. Batink,Eric A. van Royen,Martin Pfaffendorf,Pieter A. van Zwieten

Pharmacologic characterization in vitro and in vivo of iodine 123-labeled derivatives of the beta-adrenoceptor antagonist CGP12177, designed for the imaging of cardiac beta-receptors.

1996

Eric A. Dubois
G. Aernout Somsen
J. D. Bos
Anton G. M. Janssen
Gerard J. Boer
Harry D. Batink
Eric A. van Royen
Martin Pfaffendorf
Pieter A. van Zwieten

Background Potential new radioligands for the noninvasive imaging of cardiac β-adrenoceptors with single-photon emission computed tomography were investigated.

Keywords:

Radiology
Single-photon emission computed tomography
Antagonist
Iodine-123
Heart failure
In vivo
Emission computed tomography
Nuclear medicine
Medicine
Adrenergic receptor
In vitro
β receptor
noninvasive imaging
β adrenoceptor antagonist

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