Sustainable Routes to Amines in Recyclable Water Using ppm Pd Catalysis

Abstract Reactions are discussed that lead to the valuable amine functional group in aromatics and heteroaromatics, carried out under sustainable conditions in water enabled by micellar catalysis. Thee new technologies are general, and have been successfully applied to intermediates associated with several targets in the pharmaceutical space. Each relies on ppm levels of Pd used either as solubilized catalysts or on the surface of easily formed nanoparticles. These processes also feature opportunities for recycling of the aqueous medium, thereby overall, offering greener, environmentally responsible methods for introducing nitrogen-containing functionality into organic molecules.