Estimating the size of HIV-negative MSM population that would benefit from pre-exposure prophylaxis in Florida

Abstract Purpose This study aimed to estimate the size of the population of men who have sex with men (MSM) in Florida with high-risk behaviors that would indicate eligibility for pre-exposure prophylaxis (PrEP) use. Methods Three methods were used to estimate the MSM population. Estimates from the three methods were averaged, and the number of MSM living with HIV in each zone improvement plan (ZIP) code was subtracted. Results The average MSM estimate was 1–2,184 men (1.5–22.9%) by ZIP code. The size of the MSM population with indications for PrEP use was highest when using estimates of MSM with more than one sex partner in the past year obtained from the National HIV Behavioral Surveillance system and lowest when the MSM estimate was multiplied by 24.7% (percent of MSM with PrEP indications from other studies). Conclusion Areas with high numbers of MSM with PrEP indications could be targeted with information to reduce HIV acquisition.