Relationship of Combined VEGF,CEA and CA199 Dynamic Assay and Hepatic Micro-metastasis of Gastric Carcinoma

Objective To study the correlation and its clinical significance between the serum VEGF,CEA,CA199 levels and liver micro-metastasis of gastric carcinoma.Methods 168 patients with gastric carcinoma were studied in our study and were divided into simultaneous hepatic metastasis group (SHMG)and no simultaneous hepatic metastasis group (NSHMG).All of the patients,blood was harvested before and after 1st,3rd,6th,12nd,18th,24th month of the treatment,the serum VEGF,CEA were assayed by enzyme linked immunosorbent assay (ELISA),and the serum CA199 level was evaluated by Adopt Micro-paRticle enzyme immunoassay analysis(MEIA).Results Before the treatment,the positive rates of VEGF,CEA,CA199 in NSHMG and SHMG were 25.0% and 87.5%,16.1% and 51.8%,33.0% and 50.0%,respectively(P0.01).After the treatment,the SHMG's negative rates of VEGF,CEA,CA199 at 1st,3rd,6th,12nd,18th,24th month were higher than those of NSHMG with statistical difference.In NSHMG,there were 43 patients with no recurrence,40 patients with hepatic micro-metastasis and 29 patients with recurrence or extraheptic metastasis.The CEA and CA199 double positive rates were 30.2%,77.5%,75.9% respectively and VEGF,CEA,CA199 triple postivie rates were 34.8%,92.5% and 86.2%,respectively.Conclusion For patients with gastric carcinoma,the dynamic and combined assay of serum VEGF,CEA and CA199 levels might be beneficial for early detection of hepatic micrometastasis.