Effect of SMT on experimental viral myocarditis

AIM: A model of viral myocarditis was established to study the effect of SMT(A Chinese patient drug) on myocarditis with CVB 3 infected mice METHOD: CVB 3 infected BALB/c mice show myocarditis physical charicteristics at day 4,and myocardial pathological changes reach topmost at day 8,and through this way a model of viral myocarditis was established successfully Through the change of mice weight,the contents of AST,LDH,SOD and MDA in sera,virus titer in myocytes,the change of myocardial pathology and ultrastructure,we studied the effect of SMT on myocarditis of mice infected with CVB 3 RESULT:SMT could promote the growth of mice weight;reduce the content of AST,LDH and MDA in sera;improve myocardial pathological changes and myocardial ultrastructure;repress virus replication in myocytes CONCLUSION: SMT had therapeutical effect on murine myocarditis,and the mechanism of this effect was associated with the effect of antioxidation and repressing virus replication in myocytes