Late mortality in two-year survivors of hematopoietic cell transplantation (HCT) performed in children and adolescents: Report from the BMT-Survivor Study

8507 Background: We assessed overall and cause-specific late mortality [death occurring 2 or more years (yrs) after HCT] in a retrospective cohort of 862 patients (pts), unedrgoing HCT between 1974 and 1998, before the age of 21 yrs, and surviving at least 2 yrs. Methods: Vital status information was obtained from medical records, National Death Index, and Social Security Death Index. Age- and sex-standardized mortality ratios (SMR) were calculated using US population mortality data. Results: Primary diagnoses included ALL (n=212), AML (n=205), SAA (n=113), HD/NHL (n=67), inborn errors of metabolism (IEM: n=81), and other diagnoses (n=184). Types of HCT included related donor (RD: n=496), unrelated donor (URD: n=186), and autologous (A-HCT: n=180). Median age at HCT was 9.3 yrs (0.1–20.9) and length of follow-up 10.1 yrs (2.0–28.4). A total of 182 (21%) late deaths were observed. The cohort was at a 20-fold increased risk of late death when compared with the general population. Leading causes of deaths in...