The Involvement Of Catecholamines In The Seizure Mechanism Induced By α-Guanidinoglutaric Acid In Rats

Guanidino compounds, e.g., γ-guanidinobutyric acid1, guanidinoacetic acid2, N-acetylarginine3, taurocyamine4, methylguanidine5 and homoarginine 6, are known to induce epileptic seizures when administered intracisternally into rabbits. α-Guanidinoglutaric acid (α-GGA) is a guanidino compound first found in the cobalt-induced epileptogenic focus tissue in the cerebral cortex of cats7. α-GGA was also found to induce epileptic seizures when administered into the sensory motor cortex of rabbits8 and when administered intraventricularly into rats9.