The ototoxicity of carboplatin in retinoblastoma children

Objective To analyse the ototoxicity of carboplatin in retinoblastoma children during chemecotherapy with CEV methods.Design Retrospective case series.Participants 95 children(135 eyes) with retinoblastoma in Department of Ophthalmology in Beijing Children's Hospital from November 2009 to February 2011.Methods Pure-tone audiometry,distortion-product otoacoustic emission and auditory brainstem response were used to measure the hearing threshold of bilateral ears at 1st,3rd,and 6th chemecotherapy respectively.Main Outcome Measures The hearing threshold of bilateral ears.Results Three children were found to have elevated hearing threshold during chemotherapy at the 3rd chemecotherapy among all the 95 patients.Two of them were back to normal hearing status in the following measurement.Only one child remained abnormal hearing threshold of his left ear up to 60 dB till the last measurement.Conclusion The ototoxicity of carboplatin during the chemecotherapy of retinoblastoma children is not common,while concurrent audiologic follow-up is required.