مقایسه میانگین سطح لیپوپروتئینها و آپولیپوپروتئینهای سرم بیماران مبتلا به افسردگی اساسی با گروه شاهد

Aim and Background: Major depressive disorder (MDD) is known to play a major role in the onset of coronary artery disease (CAD). Several studies demonstrated an association between dyslipidemia and MDD. The present study aimed to investigate the mean serum lipoproteins and apolipoprotein level in patients with MDD. Method and Materials: Thirty-two patients, who fully met the fourth diagnostic and statistical manual of mental disorders criteria (DSM-IV) for MDD, and 32 healthy control subjects, were enrolled in the study. Hamilton Depression Rating Scale (HDRS) was also completed. Serum levels of the total cholesterol (TC), triglyceride (TG), high density-lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), apolipoprotein A (apo A) and apolipoprotein B (apo B) were measured. Findings: Mean levels of LDL-C and apo B were significantly higher and mean levels of HDL-C and apo A were significantly lower in the MDD group compared with the control group. Total cholesterol and triglyceride levels were higher in MDD group than the control group; however, the differences were not significant. Conclusions: Patients with MDD are at the highest risk for CAD, thus evaluation of lipid profile in these patients is essential for detection and prevention of atherosclerosis to reduce the risk of cardiovascular diseases. Keywords : Lipoprotein, Apolipoprotein, Major depressive disorder