DEVELOPMENT AND CHARACTERIZATION OF NON SURFACTANT BASED EMULSION: IN -VITRO STUDY

Emulsification of castor oil in aqueous solutions of chitosan is studied without adding any additional surfactant. The main objective of this study was to evaluate the dispersion of castor oil in aqueous phase in the presence of chitosan, and how this polymer promotes the stability of the obtained emulsions. Nevertheless, chitosan promote emulsion production by increasing the matrix viscosity and provides stabilization of the oil-water interface by forming a dense hydrophilic polyelectrolytic brush on the water side of interface which present a significant barrier for coalescence - both steric and electrostatic. Chitosan stabilizes the emulsion mainly by the steric effect. These steric effects generate Vander Waals repulsion forces when two particles are too close. After loading with antiviral drug nevirapine; these emulsions were characterized in terms of phase contrast microscopy, hot stage microscopy, Fluorescence microscopy, particle size, zeta potential, viscosity, entrapment efficiency, release studies using dialysis bag method. The prepared emulsion were stable in terms of mean globule size, change in drug content and retain there cationicity. The formulated emulsions are a promising carrier for nevirapine and other lipophilic drugs.