An Analysis on Resistance Status of 2327 Strains of Bacillus tuberculosis to Multi-drugs

Objective:To investigate the resistance status of Bacillus tuberculosis to anti-tuberculosis drugs of fist and second ranks in use,and so as to provide basic data for tuberculosis(TB)prevention.Methods:Drug sensitivity of 2327 strains of B.tuberculosis isolated from clinic patients during 2003-2009 was tested with WHO recommended method.Results:The general drug resistance rate was 53.07%,and multi-drug resistance rate 22.47%.The drug resistance data of the last 2 years showed that the primary drug-resistance occupied 32.62%,and the acquired drug-resistance 67.37%.Nine cases of extraordinary drug-resistance(XDR-TB)were found among the 102 cases of multi-drug resistance(MDR-TB).Conclusions:The local drug-resistance rate of B.tuberculosis in Guiyang City is higher than the national average.The primary drug-resistance is relatively high,and there occur XDR-TB patients.It is suggested that drug-resistance mornitoring should be carried out,and so as to provide data for designing treatment plan of TB.