Effect of hypoxen on bioenergetic processes in mitochondria and activity of ATP-sensitive potassium channel

The effect of Hypoxen (HX) on bioenergetic processes in the mitochondria of heart and liver of rats connected with respiration, generation of hydrogen peroxide and activity of ATP-sensitive K-channel (mitoKATP) has been studied. It is shown that HX in the range of 0.05–10 μg/mL stimulates respiration, increases the coupling in the respiratory chain, and increases the formation of H2O2 and energy-dependent swelling associated with potassium transport in mitochondria. HX removes the inhibitory effect of ATP on the energy-dependent swelling of mitochondria and partially reduces the accumulation of H2O2 in the presence of ATP. The role of antihypoxic and antioxidant action of HX associated with the activation of mitoKATP is discussed.