The Pathology of Pelvic-Ovarian Epithelial (Epithelial-Stromal) Tumors

Abstract This chapter updates several important issues pertaining to epithelial malignancies of the ovary. These include: (1) origins, including fallopian tube and updates on the potential significance of and interpretive pitfalls with serous tubal intraepithelial carcinoma (STIC), (2) subdivisions of high-grade serous carcinoma (HGSC) that have clinical and possibly pathogenetic importance, (3) molecular parameters useful in subclassification, (4) recent data on the outcome of stage I noninvasive low-grade serous carcinomas (LGSCs; also known as micropapillary borderline tumors), and (5) the spectrum of borderline tumors of mixed epithelial type. As always mucinous tumors include both endocervical and intestinal type, with an additional gastric variant that must be kept in mind that can be associated with Peutz-Jeghers syndrome.