Granulocyte Progenitor Compartments after Allogeneic Bone Marrow Grafts

Bone marrow granulocyte colony forming cells (CFU-C) were measured in 10 HL'A compatible sibling donor-recipient pairs. The regeneration of granulocytes and CFU-C compartments were also studied in order to evaluate haemopoietic recovery. The number of nucleated bone marrow cells in the donation was 23 ±4 times 109 cells, which recipients received (3.5 ±0.4) × 108 nucleated cells/kg and (1.19 ±0.32) × 105 CFU-C/kg. This produced a bone marrow reconstitution of (67 ±26) × 105 CFU-C/kg by day 30. There was a significant correlation between CFU-C/kg given and (1) granulocyte count on day 30 (P = < 0.05) and (2) the first day of reappearance of neutrophils in the blood (P = < 0.05). a significant correlation between CFU-C/kg given and (1) granulocyte count on day 30 (P = < 0.05) and (2) the first day of reappearance of neutrophils in the blood (P = < 0.05). These results indicate that the speed and completeness of granulocyte regeneration can be predicted by measurement of the size of the CFU-C inoculant in the bone marrow graft.