Effects of pulmonary surfactant combined with BiPAP on neonatal respiratory distress syndrome at different gestational ages

Objective To analyze the effects of pulmonary surfactant combined with bi-level airway positive airway pressure ventilation(BiPAP) on blood gas index and mechanical ventilation parameters of neonatal respiratory distress syndrome (NRDS) at different gestational ages. Methods A total of 120 cases of NRDS children treated in the Central Hospital of Yuncheng from July 2016 to July 2017 were divided into early stage group (28-33 weeks), middle stage group (34-37 weeks) and late stage group (> 37 weeks), with 40 cases in each group. The three groups were treated with pulmonary surfactant combined with BiPAP noninvasive respiratory model. Arterial oxygen partial pressure(PaO2), pH value, partial pressure of carbon dioxide(PaCO2), ratio of PaCO2 to fraction of inspired oxygen (FiO2), positive end expiratory pressure(PEEP), mean airway pressure(MAP) and other values in the three groups were retrospectively compared. Results ①The time of the first medication and mechanical ventilation in the early stage group were shorter than those in the middle stage group and late stage group, while the dosage of the first medication of early stage group was higher than that in the other two groups, and there were significant differences (P<0.05). ②The level of PEEP in the early stage group was higher than that in the middle stage group and late stage groups; the level of MAP in the early group was lower than that in the other two groups, and there were significant differences (P<0.05). ③The values of PaO2, pH and PaO2/FiO2 in the early stage group were higher than those in the middle stage group and late stage group; however, the value of PaCO2 was lower than that in the middle stage group and late stage group, there were significant differences (P<0.05). Conclusions For children with NRDS at different gestational ages, pulmonary surfactant combined with BiPAP can achieve significant curative effect. Key words: Pulmonary surfactant; Bi-level airway positive airway pressure ventilation; Neonatal respiratory distress syndrome; Blood gas index; Clinical effect