CaSR polymorphisms and risk of nephrolithiasis: A meta analysis

Objective To evaluate the association between calcium-sensing receptor(CaSR) polymorphism and nephrolithiasis risk. Methods Relevant reports were searched by key words on academic data base, such as Pubmed, Web of Science and OVID. And useful studies which conformed to the criteria were included in meta-analysis and analyzed with Stata 10.0 software. Results This meta-analysis included 2 269 cases and 2 637 controls based on 12 published case-control studies from 9 articles. The overall results suggested that the variant genotypes of Arg990Gly polymorphism but not the Ala986Ser or Glu1011Gln polymorphism was associated with nephrolithiasis risk. In the stratified analysis, the Arg990Gly polymorphism would increase, the risk of nephrolithiasis remained in Caucasians and healthy population. For the Ala986Ser polymorphism, increased nephrolithiasis risk was found in studies of Asians and healthy population whereas reduced risk was found in studies of primary hyperparathyroidism (PHPT) patients. Conclusions These results suggests that the Arg990Gly polymorphism might contribute to the nephrolithiasis susceptibility, especially in studies using Caucasians and healthy population. The Ala986Ser polymorphism might modulate the nephrolithiasis risk in specific populations. Key words: Nephrolithiasis; Calcium-sensing receptor; Polymorphism