Monocyte chemotactic protein 1-induced protein and cerebral ischemia

Cerebral ischemia-induced inflammatory cascade reaction may aggravate nerve tissue damage and destroy blood-brain barrier, and angiogenesis after ischemia can improve nerve function. Inhibiting inflammatory response after stroke, promoting angiogenesis and protecting blood-brain may reduce nerve tissue damage and promote recovery of neurological function. Monocyte chemotactic protein 1-induced protein inhibits inflammatory signaling pathways through degradating proinflammatory cytokine mRNA. Its unique biological characteristics also suggest that it has the potential protective effect in cerebral ischemia. This article focuses on the roles of monocyte chemotactic protein 1-induced protein in cerebral ischemia. Key words: Brain Ischemia; Chemokine CCL2; Inflammation; Cytokines; Neovascularization, Physiologic; Blood-Brain Barrier; Neuroprotective Agents