Diffuse large B-cell lymphoma of tonsil and testis: unexpected metastatic sequence

Introduction: Diffuse large B-cell lymphoma is the largest subtype of non-Hodgkin’s lymphomas, and is characterized by frequent extranodal presentation. The most common extranodal locations of non-Hodgkin’s lymphomas are: stomach, bone, liver and testis. Simultaneous detection of multiple extranodal involvements during consultation is quite uncommon, and the majority of cases are characterized by gastric or intestinal localization. Case Report: This study has found an extranodal involvement of tonsil and testis by diffuse large B-cell lymphoma. Symptoms of tonsil lymphoma were seen one year before the same type of lymphoma appeared in the testis. Conclusion: The clinical course, similarity in the histological findings and the immunoprofile between the two organs suggested a possibility of metastatic diffuse large B-cell lymphoma from the tonsil to testis, which would be the first reported case.