Enantioselective 4-Hydroxylation of Phenols under Chiral Organoiodine(I/III) Catalysis
2017
A procedure for the intermolecular enantioselective dearomatization of phenols under chiral (I/III) catalysis is reported. This protocol employs 3-chloroperoxybenzoic acid ( m -CPBA) as the terminal oxidant together with a defined C 2 -symmetric aryl iodide as the effective organocatalyst. This enantioselective reaction proceeds with complete selectivity under mild conditions and enables the hydroxylative dearomatization of a number of phenols to give the corresponding p -quinol products with up to 50% ee .
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