Inhibitory effect of dglitazone on tumor angiogenesis in nude mice transplants of hepatic carcinoma

Objective To investigate the effect of ligand of peroxisome proliferator-activated receptor gamma (PPAR) on tumor angiogenesis in nude mice transplants of hepatic carcinoma. Methods RT-PCR was use to detect the PPAR mRNA expression in hepatic carcinoma tissuse, and the expression of Ⅷ factor and VEGF in the ciglitazone-treated nude mice transplants of hepatic carcinoma was assayed by using SP method and Western blot. Results PPAR mRNA was detected in tumor,and in ciglitazone-treated group,tumor grew slowly [ (207.5 + 192.9) mm3 ,P <0.05 ]. The MVD and VEGF expression in ciglitazone-treated group were lower than in control group ( P < 0.05 and P < 0.01, respectively). Conclusion Ciglitazone can inhibit the growth of hepatic carcinoma by suppressing the angiogenesis. Key words: Peroxisome proliferator activated receptor;  Carcinoma,hepatocellular;  Angiogenesis